9 of the Best Boutique Hotels in Rome

The Hoxton Rome opened in 2021 as the brand’s first Italian outpost, in a redeveloped 1970s building in the affluent Parioli district. Ennismore Design Studio designed the 192 rooms across seven floors with reference to classic Italian cinema. Fettle Design handled the public spaces, including the airy modernist lobby.

Nomos Hotel occupies a former Franciscan monastery in Rome's Regola district, adjacent to the church of San Paolo alla Regola. Italian artisan-designer Henry Timi (in his first hospitality project) led the conversion, applying what he calls 'material minimalism' across plaster, terracotta, terrazzo and travertine.

Six Senses Rome occupies the 15th-century Palazzo Salviati Cesi Mellini in centro storico, between the Trevi Fountain and the Pantheon. Spanish architect Patricia Urquiola led the conversion, layering modern silhouettes across 96 rooms and suites with the building’s original travertine, marble and cocciopesto plaster.

Orient Express La Minerva opened in 2025 as the first standalone Orient Express hotel, in a 17th-century palazzo on Piazza della Minerva, footsteps from the Pantheon. Franco-Mexican artist-architect Hugo Toro designed the 93 rooms and suites, blending Art Deco with nods to the brand's rail heritage.

Casa Monti opened in summer 2024 as the first Italian hotel from the Kampf family, the small group behind La Fantaisie in Paris and Cœur de Megève. The 36 rooms occupy a historic Roman building on Via Panisperna in Monti, the city's oldest creative quarter, with interiors by Parisian designer Laura Gonzalez.

Palazzo Talìa occupies a 16th-century palazzo near the Trevi Fountain, the former Collegio del Nazareno school. Studio Luca Guadagnino designed the public spaces and Terrace Suite - the studio’s first hospitality project. The 26 rooms are by Mia Home Design Gallery and Laura Feroldi Studio, set above a tropical courtyard.

W Rome opened in 2021 as the brand’s first Italian hotel, spanning two adjacent 19th-century palazzos on Via Liguria, in the Ludovisi district near the Spanish Steps. New York studio Meyer Davis designed the 162 rooms and suites, juxtaposing the city’s traditional architecture with bold colours and modern prints.

Chapter Roma occupies a 19th-century building in the Renaissance-era Regola district near the Jewish Ghetto. Johannesburg-based designer Tristan Du Plessis led the interiors across 42 rooms, drawing on the neighbourhood’s industrial heritage with exposed brick, black-steel furniture and bronze accents.

Mama Shelter Roma opened in 2021 as the brand’s first Italian hotel, in a tower-block building in Trionfale, just north of the Vatican. Designer Benjamin El Doghaïli of Mama Design Studio led the 217 rooms over six floors, with cartoon goddesses on ceilings and emperors and pizzas woven into the carpets.