Italy’s boutique hotels concentrate in four storied destinations: Rome, Venice, Lake Como and Milan. From restored 15th-century palazzos in Rome’s centro storico to Grand Canal-facing Byzantine and Renaissance palaces in Venice, modernist lakeside retreats on Como’s eastern shore and 1950s rationalist buildings in Milan reborn under Patricia Urquiola and Matteo Thun. The collection ranges from six-suite hideaways to 217-room heritage buildings, with Michelin-starred dining, Roman baths, infinity pools over the Alps and rooftop terraces over Brera.
All properties sit within Bali's volcanic landscapes and cultural temples, where ancient traditions meet contemporary design across the island's diverse regions.
The Hoxton Rome opened in 2021 as the brand’s first Italian outpost, in a redeveloped 1970s building in the affluent Parioli district. Ennismore Design Studio designed the 192 rooms across seven floors with reference to classic Italian cinema. Fettle Design handled the public spaces, including the airy modernist lobby.
Aethos Milan reopened in March 2026 following a complete renovation that upgraded the hotel to five-star status. Set behind an unassuming façade in the Navigli district, the 35 rooms occupy a building organised around a leafy courtyard, just steps from the Darsena waterfront. Each room references the original architectural lines.
Six Senses Rome occupies the 15th-century Palazzo Salviati Cesi Mellini in centro storico, between the Trevi Fountain and the Pantheon. Spanish architect Patricia Urquiola led the conversion, layering modern silhouettes across 96 rooms and suites with the building’s original travertine, marble and cocciopesto plaster.
Nomos Hotel occupies a former Franciscan monastery in Rome's Regola district, adjacent to the church of San Paolo alla Regola. Italian artisan-designer Henry Timi (in his first hospitality project) led the conversion, applying what he calls 'material minimalism' across plaster, terracotta, terrazzo and travertine.
Orient Express La Minerva opened in 2025 as the first standalone Orient Express hotel, in a 17th-century palazzo on Piazza della Minerva, footsteps from the Pantheon. Franco-Mexican artist-architect Hugo Toro designed the 93 rooms and suites, blending Art Deco with nods to the brand's rail heritage.
Casa Monti opened in summer 2024 as the first Italian hotel from the Kampf family, the small group behind La Fantaisie in Paris and Cœur de Megève. The 36 rooms occupy a historic Roman building on Via Panisperna in Monti, the city's oldest creative quarter, with interiors by Parisian designer Laura Gonzalez.
Palazzo Talìa occupies a 16th-century palazzo near the Trevi Fountain, the former Collegio del Nazareno school. Studio Luca Guadagnino designed the public spaces and Terrace Suite - the studio’s first hospitality project. The 26 rooms are by Mia Home Design Gallery and Laura Feroldi Studio, set above a tropical courtyard.
W Rome opened in 2021 as the brand’s first Italian hotel, spanning two adjacent 19th-century palazzos on Via Liguria, in the Ludovisi district near the Spanish Steps. New York studio Meyer Davis designed the 162 rooms and suites, juxtaposing the city’s traditional architecture with bold colours and modern prints.
Il Palazzo Experimental occupies the former Adriatica naval transport headquarters, a Renaissance palazzo on the Zattere in Venice’s Dorsoduro district. French designer Dorothée Meilichzon led the conversion of the 32 rooms, blending Memphis Movement colours with traditional Venetian terrazzo, Marmorino walls and Breccia Capraia marble.
Mama Shelter Roma opened in 2021 as the brand’s first Italian hotel, in a tower-block building in Trionfale, just north of the Vatican. Designer Benjamin El Doghaïli of Mama Design Studio led the 217 rooms over six floors, with cartoon goddesses on ceilings and emperors and pizzas woven into the carpets.
Room Mate Giulia occupies a late 19th-century building on Via Silvio Pellico, beside the Galleria Vittorio Emanuele II and steps from Piazza del Duomo. Spanish architect Patricia Urquiola designed the 85 rooms across five categories, with custom Cassina furniture and a Milanese palette of pink marble, terracotta and moss green.
Casa Brivio occupies two 1960s and 1970s buildings between Torre Velasca and the Colonne di San Lorenzo, inspired by Luigi Caccia Dominioni’s rationalism. The hotel is a project by cousins Filippo and Alberico Brivio Sforza, with architecture by Matteo Thun & Partners and rooms by Cassina Custom Interiors.
Chapter Roma occupies a 19th-century building in the Renaissance-era Regola district near the Jewish Ghetto. Johannesburg-based designer Tristan Du Plessis led the interiors across 42 rooms, drawing on the neighbourhood’s industrial heritage with exposed brick, black-steel furniture and bronze accents.
Crossing Manzoni occupies two floors of a neoclassical palazzo on Via Gerolamo Morone, a quiet street long home to prominent Milanese families, including that of writer Alessandro Manzoni. The six suites sit between the Quadrilatero d’Oro and Teatro alla Scala, a discreet pied-à-terre in the heart of Milan.
Vico Milano opened in 2021 after a two-and-a-half-year renovation led by Sicilian architect Giuseppe Alito with founder Neri Baccheschi Berti. The seven suites sit at the back of a residential courtyard off Corso Genova, in a building that once produced Legnano racing bicycles and later housed the family’s 1990s fashion brand Bungai.
Il Sereno opened in 2016 on Lake Como’s eastern shore, in Torno. Built on a former state-owned darsena (boathouse), the modernist building reinterprets Giuseppe Terragni’s rationalist architecture with floor-to-ceiling glass and vertical wooden slats. Spanish architect Patricia Urquiola designed the 40 suites, from 50 to 200 sqm.
